Two approaches for the detection of linkage between a marker gene and a polygene affecting a quantitative trait have been described in the literature. The first (1) is appropriate when marker gene and polygene are both at intermediate frequencies in the population of interest. This approach involves an analysis of variance between full sibs or half-sibs grouped according to their marker genotypes. The second (2) is appropriate when both marker gene and polygene are at high frequencies in the population of interest. This method involves crossing to a tester strain that is close to fixation for the alternative alleles of both marker gene and polygene; followed by an analysis of variance between backcross or F2 progeny grouped according to their marker genotype. The purpose of this contribution is to obtain some notion of the size of the experiments that would be needed in order to detect linkage under each of the above experimental designs.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 3, Madrid, Spain, 289–294, 1974
|Download Full PDF||BibTEX Citation||Endnote Citation||Search the Proceedings|
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.