The existance of a major histocompatibility complex (MHC)has long been observed in several mammalian species but only recently bovine studies have received more attention. The histocompatibility antigens, generally determined on lymphocytes, can be understood as the phenotypic expression of a complex of multiple alleles, very closed located in a small region of an autossomal chromosome (Gotze, 1977). Caldwell et al. (1977) reported evidence of SD antigens and latter Caldwell (1979) presented evidence for the inheritance of one SD locus in Holstein breed of cattle. Spooner et al. (1978) , using reagents from skin grafting or lymphocyte immunization between dam-offspring pairs, showed that at least 17 factors were inherited in a simple Mendelian fashion, all of them controled by the same chromosome region. Evidence for a number of closely-linked loci was presented by those authors.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 7. Symposia (1), , 325-330, 1982
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