Increasing attention is being given to the use of cattle that are innately resistant to trypanosomiasis (a trait termed trypanotolerance) in livestock development projects in tsetse- infested areas of Africa. At the same time, research is being carried out into the factors associated with innate resistance. These include the capacity to control trypanosome growth and the development of effective immune responses. It would appear that the rate of parasite multiplication is regulated by the availability of host-derived growth factors, while the rate of parasite destruction is controlled by the efficiency of the host antibody response. Host antibody production, in turn, is at least partly controlled by a parasite-induced response which influences the final stages of plasma cell maturation and antibody secretion. If the mechanisms underlying these factors are identified, it might be possible by immunisation, by specific drug treatment or by transfection of appropriate genes to produce highly productive cattle which are resistant to trypanosomiasis.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XI. Genetics of reproduction, lactation, growth, adaptation, disease, and parasite resistance., , 551–562, 1986
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