SUMMARY Restriction fragment length polymorphisms are a new class of genetic marker uncovered by means of recombinant DNA technologies, that promise to be exceedingly numerous in agricultural livestock species. These markers open broad prospects for the mapping and breeding manipulation of quantitative trait loci CQTL). Mapping a large number of probes at a species level, could be most readily accomplished by utilizing wide crosses between divergent races or breeds Simulation studies show that it would take about 125 random polymorphic markers to provide 80% coverage of the cattle genome, at a maximum spacing such that all points are within 20 cM of a marker. Marker-QTL linkage studies, based on data from sire daughter progeny groups, could map 50% of the QTL segregating in a population, once five sires have been evaluated, and virtually all segregating QTL once 20 sires have been evaluated. This would involve about 1000 daughters each evaluated for five traits and 100 markers per sire. Selection programs based on marker-evaluated sires could contribute an additional 25-50% overall genetic progress. Costs would be about $1000,000 per marker-evaluated sire, and discounted returns about 1.5-3.0 x costs.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XII. Biotechnology, selection experiments, parameter estimation, design of breeding systems, management of genetic resources., , 57–63, 1986
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