Spontaneous and induced mutations may increase selection response. Negative effects of mutations can be overcome by selection. However, it seems to be hardly possible to accumulate induced mutations in unselected populations. In some experiments with Drosophila great selection responses could be traced back to effective factors with large effects. This indicates that mutants for bristle number show a leptokurtic distribution which leads to big differences of selection response between replicates.

E. Grundl, L. Dempfle

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 177–183, 1990
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