Two F2 populations of mice representing diverse genetic backgrounds were generated from crosses between long-term high 42-day body weight selected and control lines of mice. Haplotypes for restriction fragment length polymorphisms (RFLP’s) at the growth hormone (GH) locus, GH" and GHC, were identified for approximately 150 mice in each F2 populations and analyzed to determine the effect of naplotype on body weight. The two populations yielded apparently contradictory results. In one of the populations, the GHh allele which was fixed in the selected Pn was associated with lower 42-day weight, as .we found in a previous study with a different population. In the other set, the GHft allele which was present at a frequency of 0.60 in the selected Po was associated with higher weights in the F2; however, these results were confounded by a dearth of ST"STh homozygotes and the presence of heterotic effects on weight.

D. C Winkelman, R. B Hodgetts

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 86–89, 1990
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