The ratio of selection response due to mutation to total response is analyzed in a general genetic model which allows more than two alleles segregating at a locus. Analytic results are obtained for weak selection. For strong selection the ratio is evaluated by simulations. The results show that Hill’s prediction (1982, Genet. Res. 40: 255-278) of selection response from mutation slightly overestimates the ratio. Significant differences between our and Hill’s predictions are likely to occur for relatively strong selection for more than 100 generations. The ratio depends very much on the parameters. For reasonable choices of parameter values the ratio is about 10 to 25% at t = 25, and 25 to 50% at t = 50, where t is the generation number of selection.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 301–305, 1990
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