Lines of mice divergently selected for 10 week body weight were investigated for the presence of segregating alleles with large effect on weight. It appears that the X chromosome may act as a "major gene" but whether due to single or multiple allelic differences has not yet been determined. The possible role of sex-linked genes in the response to selection is considered.

I. M Hastings

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 317–320, 1990
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