Restriction fragment length polymorphism (RFLP) analyses of swine leukocyte antigen (SLA) class I genes were performed on 32 litters of Duroc pigs to identify genetic markers associated with performance traits in the pig. Southern blotting and hybridization procedures were performed on genomic DNA isolated from white blood cells, by using Pvu II endonuclease and a swine major histocompatibility complex (MHC) class I probe. Of the 13 different bands observed, 8 were polymorphic. Least squares procedures, using typical animal breeding models, and a mixed animal model with complete relationships were used to analyze the data. Results from the least squares analyses suggested that the polymorphic swine MHC class I restriction fragments accounted for 6% and 4% of the variation for average daily gain and backfat, respectively. When the animal model was used, however, smaller effects were associated with those class I fragments. These results suggest that the swine MHC has a small, but significant effect on performance in the pig.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 125–128, 1990
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