Abstract

Chicken growth hormone ( GH ) receptor gene was isolated from a genomic library, and its promoter region and several exons have been sequenced. The coding fragments span about only 10 kilobase, nnliv^ the human GH receptor gene, which spans at least 87 kilobase. Sex-linked dwarfism m chicken is a recessive genetic disorder that is characterized bv undetectable levels of hepatic GH-binding activity and a mutation in the GH receptor gene. With the region specific DNA probes from our genomic cloning, characterization of the GH receptor gene indicates that sex-linked dwarf chickens have a deletion of approximately 2 kilobase portion in the intracellular domain of the receptor gene. These direct evidence demonstrate that sex-linked dwarfism could result from a defeat in the structural gene of the GH receptor gene in chicken

N. Li, R. Dai, C. Wu, Y. Chen

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 13–16, 1994
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