SSCP analysis of the bovine growth hormone (bGH) gene in Israel-Holstein cattle uncovered five intragenic haplotypes. Four, differed among themselves at two sites; while the fifth, denoted Haplotype E, differed from the others at six sites. A number of lines of evidence indicate that Haplotype of E is of indicine origin. Haplotype E had significant increasing effects on percent protein and kg protein/yr, and an almost significant reducing effect on milk somatic cell counts; but did not affect total milk, fat percent, or fertility. Sequencing of 1500 bp of bGH uncovered seven nucleotide differences uniquely distinguishing the putative indicine and taurine haplotypes. When extrapolated to the entire genome these nucleotide differences have major implications for QTL mapping and cattle genetic improvement

A. Lagziel, E. Lipkin, E. Ezra, Moshe Soller

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 25: Lactation; growth and efficiency; meat quality; role of exotic breeds in the tropics; design of village breeding programmes;, , 63–66, 1998
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