In previous work, one mouse line was selected for resistance to fescue toxicosis (R) and a second line was selected for susceptibility (S). Post-weaning growth of R mice was less severely depressed by a toxic fescue-containing diet than was growth of S mice. The current experiment was conducted to determine whether long term reproduction of mice on a toxin- containing (+) versus non-toxic (-) diet was more severely depressed in S than in R mice. Twenty-eight mating pairs per line x diet combination were cohabited continuously for 36 weeks. Percentage changes in reproductive traits of mice on the toxin-containing diet, for R and S pairs respectively, were -11 and -28 for total number of offspring bom, -7 and -24 for total number of offspring weaned, -11 and -13 for total number of litters produced per pair, -29 and-41 for grams of offspring weaned, and +1 and -1 for pup survival percentage to weaning. Selected lines differed in adaptation to the toxic diet as measured by its effect on several components of long term reproduction.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 27: Reproduction; fish breeding; genetics and the environment; genetics in agricultural systems; disease resistance; animal welf, , 307–310, 1998
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