Growth traits are economically important traits in livestock. It has been shown that these traits are under the control of multiple genes. Genetic marker information on related genes can be used to facilitate selection and breeding through marker assisted selection (MAS) in domestic animals. Insulin-like growth factor II (IGF-II) belongs to a family of structurally related polypeptides, which includes IGF-I, insulin and relaxin (Blundell and Humbel, 1980; Dafgard et al., 1985). IGF-II is important in the fetus (Han et al., 1987). It plays a key role in preadolescent growth, influencing fetal cell division and differentiation. IGF-II knockouts were shown to have significant fetal growth retardation, especially in the early stages of gestation (DeChiara et al., 1990). On the other hand, transgenic mice with overexpression of IGF-II were shown to have organ overgrowth and tumor formation (Ward et al., 1994, Rogler et al., 1994). Therefore, the IGF-II gene may be a good candidate gene for growth. Detecting genetic variations in the IGF-II gene and relating them to growth rate could be helpful in development of marker-assisted selection (MAS) programs in animal breeding. This study was designed to examine the IGF-II gene for possible polymorphism and to test the association of the polymorphisms with growth traits in Angus beef cattle. 

Q. Zhao, M. E Davis, H. C Hines

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 11, , 11.44, 2002
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