In the last decade, advances in molecular genetics have made it possible to dissect the genetic variability of complex traits into quantitative trait loci (QTL). In France, two large programmes were carried out for QTL detection. The first one, in collaboration with the French artificial insemination industry, was a typical granddaughter design and used national records for milk production and health traits. This programme, now completed, intended to detect genes responsible for within breed variability, i.e. the variability available for selection (Boichard et al, 2002). The second one, carried out at the INRA experimental farm of Le Pin-Au-Haras (Normandy, France), and still running, has intended to detect genes responsible for the variability between the Holstein and Normande breeds. The purpose of the present paper was to describe its design, i.e. the current family structure obtained from specific reproduction and mating methods and the traits recorded. Finally, the expected QTL detection power, based on the current design,  was estimated by simulation. 

H. Larroque, Y. Gallard, L. Thaunat, Didier Boichard, J. J Colleau

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 1, , 1.42, 2002
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