Bovine leukocyte adhesion deficiency (BLAD) is an autosomal recessive genetic disorder in Holstein cattle (Waldrop et al., 1987). It is caused by a point mutation which substitutes guanine to adenine in CD18 gene, resulting substitution of aminoacid aspartic acid to a glycine in D128G position (Shuster et al., 1992). This change causes a lack of performance of Mac1 (CD11b/CD18) a surface glycoprotein of neutrophils, which interfers in immune response against bacterial infections. This results in lack of adhesion and migration capability of neutrophils to inflammatory tissues. Therefore homozygote cases are prone to recurrent infections such as pneumonia, diarrhea, gingivitis, delay in wound healing, enteritis, neutrophilia and death in early months of life (Hagemoser et al., 1983 ; Nagahata et al., 1997 ; Kehrli et al., 1990).
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 1, , 1.83, 2002
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