The Bovine Spongiform Encephalopathies (BSE) is a neuro-degenerative disease characterised by the accumulation of an abnormal protease-resistant isoform of the prion protein in brain. The bovine prion gene extends over 20 kb, and the mRNA, consisting of three exons, is 4244 bp long. In the coding region of the gene, only one polymorphism has been identified to date, in a octapeptide repeat region, that can contain either 5, 6, or 7 copies of a motif of 8/9 amino acids (Pro, Gln, Gly, [Gly], Gly, Gly, Trp, Gly, Gln). To date, polymorphism of this octarepeat region is not correlated to incidence of BSE, although the high proportion of genotype 6:6 was demonstrated among the affected animals (Goldman et al., 1991). This polymorphism has been analysed in several cattle breeds and the results are summarised in Table 1.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.4, 2002
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