Leukemia of cattle is a chronic tumor disease caused by bovine leukemia virus (BLV). BLV is an oncogenic retrovirus, which generates B-cell lymphocytosis, leukemia and lymphosarcoma of sheep and cattle. Persistent lymphocytosis (PL) is generated in 30 % of cows with BLV infection. PL is a subclinical stage of BLV infection. Development of PL is under the genetic control of the host. Alleles of BoLA-DRB3 influence the subclinical development of BLV infection (Lewin et al., 1999). The spectrum of BoLA−DRB3 alleles associated with resistance (DRB3.2*11, *23, *28) and susceptibility (DRB3.2*8, *16, *22, *24) to PL in HolsteinFriesian breed (Xu et al., 1993) was confirmed in Black Pied breed (Sulimova et al., 1995). Resistance was dominant in contrast with susceptibility, which was inherited as a complicated recessive Mendelian trait.  

I. Udina, E. Karamysheva, S. Turkova, A. Orlova, G. Sulimova

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.23, 2002
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