Scrapie in sheep has been recognised for over two centuries in several countries (e.g. Stamp, 1962 ; Parry, 1983). It is an important transmissible spongiform encephalopathy (TSE) that is fatal and incurable. The incidence of natural scrapie in the Suffolk breed is associated with codon 171 of the prion protein (PrP) gene. Three polymorphisms for codon 171 are known : Q171 - recessive allele associated with manifestation of scrapie ; R171 – dominant allele associated with resistance ; and, H171 – allele considered as neutral with respect to scrapie susceptibility (Hunter et al., 1997a). 

L. Prokopova, R. M Lewis, W. S Dingwall, G. Simm

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.44, 2002
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