The identification of unknown trait genes in livestock has hitherto often relied on the candidate gene approach and on the positional candidate gene approach, in which information on the position of the gene locus is combined with comparative maps primarily between the livestock species and human. In a number of cases this approach has proved efficient when genes with a biological function matching the phenotype of interest could be identified. However, for traits without a clear human/mouse counterpart mapped to the region of interest, the success relies on the resolution of the comparative maps. For cattle a step towards a high-resolution comparative map was taken with the cattle-human whole genome comparative radiation hybrid map (Band et al., 2000). This map showed what was invisible in the chromosome paints previously used to define blocks of conserved synteny between human and cattle (e.g. Hayes, 1995), namely numerous intra-chromosomal rearrangements. 

P. H Nissen, B. Thomsen, C. Bendixen

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.38, 2002
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