An efficient selection on the PrP gene has been implemented for 4 years in all the French sheep breeds. Its impact on genetic variability were measured on 4 representative French sheep breeds by using genealogical and molecular data. The allele's frequency and the Hardy-Weinberg heterozygosity confirm the expected dramatic loss of genetic variability at the PrP gene and show a loss, to a lower extent, at the 5 marker loci located in the PrP region. The 24 other "neutral" markers, as well as the genealogical data indicate that the genetic variability was not greatly affected. This trend has to be modulated depending on the breed, i.e. on their initial situations (population size, PrP frequencies) and their selection strategies.

I. Palhiere, M. Brochard, E. Verrier, K. Moazami-Goudarzi, Y. Amigues, Francis Barillet, B. Bed'Hom, B O Bibé, J Bouix, D. Francois, C. Leymarie, T. Pantano

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 30.10, 2006
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