The objectives of this study were to: (1) identify single nucleotide polymorphisms (SNPs) in the CXCR2 chemokine receptor gene in Canadian Holsteins; (2) assess the association of SNPs with estimated breeding values (EBVs) for somatic cell score (SCS), and other health and production traits in Canadian Holsteins, and (3) evaluate the sensitivity of DNA pooling for detecting low frequency SNPs. Five previously reported SNPs were identified in CXCR2. One SNP (CXCR2+777) was genotyped and found associated with EBVs for SCS (P=0.06) and fat yield (P=0.05). The DNA pooling technique was sensitive enough for detecting SNPs with allele frequencies as low as 1% within the population.

I. Leyva, Flavio S Schenkel, B. S Sharma, G. B Jansen, Niel A Karrow

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 22.47, 2006
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