Abstract

Within a small region, there can be multiple quantitative trait loci (QTL) underlying phenotypes of a trait. Simultaneous fine mapping of closely linked QTL needs to remove confounded shade effects among QTL within such a small region. We propose a variance component method using combined linkage disequilibrium (LD) and linkage information with a reversible jump Markov chain Monte Carlo (RJMCMC). In a simulation study, RJMCMC clearly removes the shade effects between three closely linked QTL located at 54.5, 65.5 and 81.5 cM across the region of 140 cM, using 50 markers (40 markers are densely positioned at 1 cM interval from 50-90 cM of the region) and data on 200 individuals. It is shown that simultaneous fine mapping of closely linked QTL can be possible.

S. H Lee, Julius HJ van der Werf

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 21.08, 2006
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