Linkage disequilibrium (LD) mapping is the use of population-wide LD between markers and genes that affect traits to detect and/or fine-map such genes. LD mapping has been used extensively to identify genes for monogenic diseases in humans. Opportunities for LD mapping in livestock are substantial because of the extensive LD that is created in livestock as a result of limited effective population sizes compared to humans. The more random nature of LD generated by drift and the genetic basis quantitative traits, however, also affects properties of statistical methods for LD mapping. The purpose here is to present and discuss opportunities for LD mapping in livestock and associated statistical methods. It is concluded that a marker map of relatively limited density will allow QTL detection in livestock and that relatively simple regression methods can be used for initial analysis, without the need for haplotype data.

Jack CM Dekkers, H. H Zhao, Rohan L Fernando

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 21.05, 2006
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