Selective sweeps of variation caused by fixation of identified major genes may have a drastic impact on the genetic gain from background polygenic variation, particularly for those loci closely linked to the major gene. Using basic theoretical arguments we propose a frequency path that maximises simultaneously the effective population size and the selection intensity applicable to the selected polygenic background by minimising the average squared selection intensity on the major gene over generations up to a given fixation time. Using a locus-based computer simulation assuming different degrees of linkage we compare the proposed path with a previous one, and show that the path proposed is very efficient in converting polygenic variation into genetic gain, especially under strong linkage.

L. Sanchez, A. Caballero, E. Santiago

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 30.17, 2006
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