The solute carrier family SLC35 comprises enzymes that transport nucleotide-sugars from the cytosol into the lumen of the endoplasmic reticulum and the Golgi apparatus. In these organelles, nucleotide-sugars are used by glycosyltranferases to synthesize the sugar chains of glycoproteins, glycolipids and carbohydrate polymers, thereby linking nucleotide-sugar transporters closely with diverse cellular functions. For example, the SLC35A3 gene encoding a UDP-N-acetylglucosamine transporter has recently attracted much interest because of its role as causative gene for complex vertebral malformation in cattle. To better understand the functions of nucleotide-sugar transporters in development and disease, we have cloned and characterized the porcine SLC35A3 gene and begun to define functionally important amino acids using site-directed mutagenesis.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 22.62, 2006
|Download Full PDF||BibTEX Citation||Endnote Citation||Search the Proceedings|
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.