Infectious disease has a significant economic impact in livestock production systems worldwide. Selection using DNA markers closely linked to, or within genes controlling resistance traits is increasingly prevalent. We review the state of quantitative trait loci (QTL) studies based on genome wide screens or targeted candidate gene studies for sheep and cattle. Infectious diseases considered include gastrointestinal nematodes, mastitis, trypanosomiasis, dermatophilosis, footrot, fasciolosis, tick and tickborne diseases. We discuss the problems and methods of moving from QTL results to quantitative trait nucleotides (QTN) by fine mapping, and comparative mapping. We highlight the utility of integrating QTL studies with large scale transcriptome studies to obtain positional-functional candidate genes, followed by gain/loss of function studies. We close with markers shown to have utility in industry applications.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 15.01, 2006
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