We simulated a genotype that reflected the observed phenotype, and that complied with Mendel's first law. Another important goal was to maximize the flexibility of our simulation so that a variety of traits, populations and underlying models could be assessed, using pedigrees where animals had neither, one or both parents known. Dominance and epistasis effects could also be included. The number of loci, their effects, density and distance apart, and the lengths of chromosomes could all be defined. The QTL effects were scaled to resemble the mean and variance of the base population of bulls. These simulated datasets of animal genotypes was based on molecular breeding values, reflected past selection and environmental error, and where the size and location of QTL effects was known but concealed, and were used to evaluate molecular breeding value analyses.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 01.44, 2006
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