We investigated the association between the gene polymorphisms on PKP2, CTTNBP2NL, SETD6 and CACNB2 and fertility, milk production, and calving ability of Holsteins in Japan. The genotype effects of the four genes were estimated to be significantly positive on conception rate (CR) and significantly negative on milk production. The genotype effects of PKP2, CTTNBP2NL and CACNB2 on calving difficulty were significantly positive. The genotype effects of CTTNBP2NL, SETD6 and CACNB2 on decreasing stillbirths were significantly negative. These results suggest that selection to increase the frequencies of allele that indicate high CR for the four genes leads to an increase in calving difficulty with a decrease in milk production as well as the indirect response of decreasing stillbirths.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Species Breeding: Dairy cattle (Posters), , 809, 2014
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