Lung samples were collected from 11,520 young cattle from a  beef processing plant.  Lung samples with lesions (cases) and healthy lungs (controls) were collected when both phenotypes were in close proximity on the viscera table.  Lung samples for 96 animals with the same phenotype (case or control) were placed in a pool; 60 pools each for case and control, and the Bovine HD array was run on all pools.  Seven SNP on BTA 3, 7, 9, 11, 14 and 15 were significant at the genome wide experiment wise error rate of 5 % (P ≤ 1.49 × 10-7).  Eighty-four SNP on 28 chromosomes  achieved a false discovery rate of 5 % (P ≤ 5.47 × 10-6).  Significant SNP were near (+/- 100 Kb) genes involved in tissue repair and regeneration, tumor suppression, control of organ size, and immunity. 

John W Keele, Larry A Kuehn, Tara G McDaneld, Shuna A Jones, Timothy PL Smith, Steven D Shackelford, Andy D. King, Tommy L Wheeler

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Genetics of Trait Complexes: Disease resistance, , 089, 2014
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