Heritabilities for the four most common human cancers were estimated using cancer prevalence among the 502,682 individuals recruited to the UK Biobank (http://www.ukbiobank.ac.uk/) and their parents. The heritability estimated from parent-offspring regressions ranged from 0.12 for lung cancer to 0.33 for prostate cancer. Our estimates were substantially smaller than previous estimates from twin studies for lung, bowel and prostate cancer whilst were similar for breast cancer, and indicate that part of the missing heritability problem in genome-wide association studies of cancer is due to twin-based heritability estimates being substantially inflated. These estimates obtained from a unique European cohort will inform future directions in cancer gene mapping and risk profiling.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Methods and Tools: Statistical methods - linear and nonlinear models, , 205, 2014
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