Abstract

Proceedings of the World Congress on Genetics Applied to Livestock Production, 11. 787 Uncovering the role of chicken IFITM-mediated viral restriction.  T. Whitehead1, A. Steyn1, J. Backeroun1, I. Bassano2, Alice Gray1, Andrew Broadbent1, P. Kellam2 and M. Fife1  Summary Interferon-inducible transmembrane (IFITM) proteins are host cell derived restriction factors. These proteins act as the cells first line of defense against invading viral pathogens. Mammalian IFITM proteins have been shown to confer antiviral resistance when challenged with a variety of both enveloped and non-enveloped viruses. For the first time, we are able to demonstrate the anti-viral role that chIFITM proteins play in restricting avian viruses in the host cell. Keywords: chicken, interferon inducible transmembrane protein, virus, replication, viral restriction.

Mark Fife, Thomas Whitehead, Angela Steyn, Jessica Benkaroun, Irene Bassano, Holly Shelton, Paul Kellam

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology - Disease Resistance 3, , 787, 2018
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