The aim of this study was to investigate the pleiotropic effects of a Socs2 gene point mutation associated to lower resistance to mastitis, an inflammation of the mammary gland, mostly due to bacterial infection by Staphylococci in dairy sheep. GWAS were performed on SCC (Somatic Cell Count), bacterial infection, animal size and milk production using a 960 custom-designed ovine SNP chip and a data set of 504 Lacaune dairy ewes. The results confirmed the strong effect of this mutation on the inflammatory response (p-value of LSCS_L1 = 3.03e-07 and p-value of abscess = 2.83e-03), a slighter effect on animal size (p-value of W_ DAY_250 = 3.71e-04) and also showed for the first time an effect of this mutation on intramammary infections (p-value of STAPH_L1 = 6.80e-04). In contrast, no effect on milk production could be confirmed (p-value of MILK_L1 = 2.01e-01), suggesting an indirect role of SOCS-2 protein on milk production. Then pleiotropy tests (CLIP test) proved pleiotropic effects of the mutation on SCC, bacterial infection, size and more indirectly on milk production. Keywords: dairy sheep, genetic resistance, mastitis, genome wide association study

Claire OGET, Charlotte Allain, David Portes, Gilles Foucras, Gwenola Tosser-Klopp, Rachel Rupp

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Biology - Disease Resistance 2, , 291, 2018
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