The objectives of this study were to perform a genome-wide association study and a functional analysis to unravel genomic regions associated with hoof lesions and potential key regulator genes affecting the resistance to infectious and horn lesions in Canadian Holstein cattle. A total of 249,709 observations from 105,450 animals were recorded by 51 hoof trimmers during the trimming activity in 1,080 Canadian herds from 2009 to 2016. For horn lesions, a total of 51 20-adjacent-SNP moving windows explained more than 0.30% of the genetic variance and these most important peaks were observed on chromosomes BTA1, BTA5, BTA6, BTA9, BTA15, BTA16, BTA20, BTA21, BTA25, and BTA28. For infectious lesions, the six most important windows (>0.30%) were observed on chromosomes BTA2, BTA3, BTA10, and BTA14. The highest peaks were observed in BTA10 (0.47%) and BTA5 (1.23%) for infectious and horn lesions, respectively. Keywords: dairy cattle, hoof health, weighted single step GBLUP, ssGWAS

Francesca Malchiodi, Flavio S Schenkel, Anne-Marie Christen, David F Kelton, Filippo Miglior

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology - Disease Resistance 1, , 694, 2018
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