Bos indicus (B. indicus) breeds are better adapted to harsh environments and tropical regions, but they often present a late puberty onset in comparison to Bos taurus (B. taurus). An understanding of the mechanisms that regulate puberty onset in B. indicus is important in order to increase cattle productivity. Liver plays a prominent role in metabolism in mammals, and considerable evidence supports a link between liver function and female fertility in cattle. Hence, it might be helpful to the study of puberty to investigate protein expression patterns in liver of Brahman heifers (a B. indicus breed). We identified 777 proteins expressed in liver and 70 of these were differentially expressed (DE) between pre- and post-pubertal heifers. The functional analysis of the DE proteins showed enriched pathways that might regulate puberty onset, such as steroid hormone biosynthesis, PPAR signaling pathway, tyrosine metabolism, arginine and proline metabolism and tryptophan metabolism. In conclusion, the proteomics approach was effective in identifying DE proteins and furthering our understanding the biological link between liver function and puberty onset.

Loan To Nguyen, Lucia F Zacchi, Benjamin L Schulz, Stephen S Moore, Marina RS Fortes

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Biology - Reproduction 1, , 256, 2018
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