Vitamin A is essential for human health and current intake levels in many developing countries such as India are too low due to malnutrition. Milk can be an important source of beta-carotene and three key genes (BCMO1, BC02, and SCARB1) that are involved in the modification and transports of beta-carotene and vitamin A have been identified to have variants that may be associated with varying levels of beta-carotene. The aim of this work was to identify Single Nucleotide Polymorphisms (SNPs) in these three genes associated with beta-carotene levels in Indian cattle and buffalo breeds. Data already available from whole genome sequencing were collected from several breeds. Polymorphic SNPs within coding regions for buffalo and cattle were used to build a custom Sequenom panel and used to genotype 2,144 animals belonging to Indian cattle and buffalo breeds and crosses for which beta-carotene level in milk was measured. A general linear model was used to determine association of these SNPs with beta-carotene levels. Several SNPs were found for cattle breed crosses, but none overlapped across the crosses. For buffalo breeds only 2 out of the 4 breeds considered had associated SNPs with one overlapping SNP for the BCMO1 gene. These SNPs could be used to develop selection strategies for improved beta-carotene in milk of Indian cattle and buffalo breeds. Keywords: cattle, buffalo, beta-carotene, BCMO1, SCARB1, BCO2, Indian.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Biology & Species - Bovine (dairy) 1, , 170, 2018
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