Despite the importance of feed efficiency (FE) for improvement of productivity and reduction of environmental impact of livestock, the selection for that trait is difficult due to its polygenic regulation. Thus, the objective of this study was to investigate the hypothalamic transcriptomic profile of high and low FE bovines to uncover the molecular mechanisms responsible for the regulation of this trait. Hypothalamic transcriptomic data from nine animals from each FE group was analysed through differential expression and co-expression analysis. Eight differentially expressed genes and nine modules of co-expression were associated to FE. Modules of genes highly expressed in high FE group was mainly related to respiratory chain and ATP production in mitochondria while low FE group seems to present an hypothalamic innate immune response. These are preliminary results and further investigation are still ongoing. Keywords: RNAseq, residual feed intake, immune response, satiety, Nellore cattle
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Biology - Feed Intake and Efficiency 2, , 233, 2018
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