The transmission ratio distortion (TRD) is defined as the departure from expected frequencies under Mendelian inheritance. Current statistical approaches to investigate TRD account for two independent scenarios, model parametrizations assuming that TRD relies on allelic or genotypic mechanisms, respectively. If compared, results may provide additional information about the mechanism underlying TRD. Both analytical approaches have been compared by Bayes factors on simulated data sets with 1,000 individuals each. Analyses revealed trustworthy patterns where the model used for simulation was systematically favoured. Moreover, the correlation between simulated and predicted distortion parameters was high (>0.85). The only weakness was suggested for genotypic TRD with small to null dominance distortions. As a whole, the comparison of allelic and genotypic TRD models must be viewed as an appealing tool that should contribute to fostering research on TRD. Keywords: Bayes factor, genetic marker, transmission ratio distortion

Joaquim Casellas, Samir Id-Lahoucine, Angela Canovas

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Biology - Reproduction 2, , 745, 2018
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