Validation of candidate causative variants on milk composition and cheese-making properties in Montbéliarde cows In a previous study, we identified candidate causative variants for milk protein and fatty acid composition. We designed these variants on the custom part of the EuroG10K BeadChip. In order to validate the effects of these candidate variants on milk composition and to estimate their effects on cheese-making properties (CMP), a genome wide association analysis (GWAS) was performed on 30 CMP and milk protein, fatty acid and mineral composition traits predicted from MIR spectra in 19,862 Montbéliarde cows. After genotypes (50K SNP + EuroG10K custom part SNP) have been imputed for all cows, each SNP effect was tested in a mixed linear model including random polygenic effects estimated with a genomic relationship matrix. We confirm here the effects of candidate causative variants located in 18 functional candidate genes on both CMP and milk composition traits. Five of these variants are missense in ALPL, SLC26A4, CSN3, RECQL4 and SCD genes. Seven are located in 5’UTR (AGPAT6), 3’UTR (GPT) or upstream (CSN1S1, CSN1S2, PAEP, DGAT1 and PICALM) regions and six are located in introns of the SLC37A1, MGST1, CSN2, BRI3BP, FASN and ANKH genes. Keywords: Montbéliarde, cheese-making properties, milk composition, candidate variants

Anne Barbat-Leterrier, Eric Beuvier, Didier Boichard, Mickaël Brochard, Agnès Delacroix-Buchet, Mohammed El Jabri, Sebastien Fritz, Yves Gauzère, Cécile Laithier, Alexis Michenet, Stéphanie Minery, Odile Rolet-Répécaud, Marie-Pierre Sanchez, Sébastien Taussat, Valérie Wolf

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology & Species - Bovine (dairy) 2, , 580, 2018
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